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Albumin: Used in the management of critically ill patients for more than 60 years

Human serum albumin is the most abundant protein in plasma, comprising 50% of total plasma protein content. Synthesized exclusively in the liver, it serves multiple important roles throughout the body, including1,2:

Maintaining plasma
colloid osmotic pressure

  •   Provides 70% to 80% of total
      plasma oncotic pressure
  •   Serves as crucial modulator of
      fluid distribution among body

Transporting key substances throughout the body

  •  Cholesterol, fatty acids
  •  Bilirubin
  •  Metal ions
  •  Enzymes
  •  Medication
  •  Toxins

Hypoalbuminemia (a serum albumin concentration of ≤ 3 g/ dL) is common in critically ill patients and is associated with worse outcomes.2 Because of its osmotic effect, most clinical uses of albumin are due to its role as a plasma volume expander. Albumin solutions have been safely and successfully used in critically ill patients for this purpose since the 1940s. Fluid resuscitation is critically important in the management of shock, sepsis, trauma, acute respiratory distress syndrome, and burns. Albumin is also used today due to its capacity to bind and carry other proteins, such as bilirubin.1

See indications for a list of ALBUKED's FDA-approved indications.

References: 1. Caracini P, Tufoni M, Bonavita ME. Clinical use of albumin. Blood Transfus. 2013; 2. Vincent J-L, Russell JA, Jacob M, et al. Albumin and the acutely ill: what is new and where next? Critical Care. 2014;18:231.



ALBUKED (Albumin [Human], USP) is available in two concentrations, 5% (ALBUKED 5) and 25% (ALBUKED 25), for the following indications: emergency treatment of hypovolemic shock, burn therapy, hypoproteinemia with or without edema, adult respiratory distress syndrome (ARDS), cardiopulmonary bypass, acute liver failure, sequestration of protein rich fluids. See Indications for additional information.

Situations in Which ALBUKED is NOT Warranted: In chronic nephrosis, infused albumin is promptly excreted by the kidneys with no relief of the chronic edema or effect on the underlying renal lesion. It is of occasional use in the rapid “priming” diuresis of nephrosis. Similarly, in hypoproteinemic states associated with chronic cirrhosis, malabsorption, protein losing enteropathies, pancreatic insufficiency, and undernutrition, the infusion of albumin as a source of protein nutrition is not justified.